johnweavermd
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Fructose is interesting. In photsynthesis it is formed before less reactive glucose.
All our cells need fructose! A healthy cell makes a bit of fructose from glucose (via the sorbitol pathway) when it is needed for genetic material at time the cell replicates (divides). Gut cells replicate every 3 days, cells that line blood vessels only once every 5 years. High blood glucose as in diabetes is unhealthy because it pushes the sorbitol pathway to produce unneeded fructose in cells which spills into blood. White rice and bread is a problem for folks who have lost their rapid acting insulin response, resulting in high glucose (causing high cell fructose). This is also important because many cancer cells are unable to make fructose so to grow their victim must eat fructose or have high blood glucose. Another reason is fructose in cells in excess of that needed to divide is metabolized to glyceraldehyde and di-hydroxy-acetone. It is a mistake to believe all dietary fructose is metabolized quickly by the liver. Many cell types metabolize fructose and it increases as we eat more fructose. Why is glyceraldehyde important? Glyceraldehyde is the most reactive sugar in body and can directly damage cell proteins it is formed in causing cell dysfunction. Many types of cells (liver, nerve, muscle etc.) can become dysfunctional. Dysfunction of cells that line coronary arteries is the leading cause of death in USA. Glyceraldehyde is small and besides damaging the cell it is formed in can moves out of cell to do more damage. How? It reacts with a protein in blood creating a junk molecule called TAGE (Toxic Advanced Glycation End product). Why is this important? TAGE is recognized by our ancient “innate immune system” as part of bacteria. TAGE in blood can attach to a cell receptor (RAGE) and set off the same inflammatory response as a few bacteria parts. In addition to being the cause of unnecessary inflammation, TAGE also increases levels of a specific vascular endothelial growth factor or VegF. Why is this important? Elevation of this VegF is a factor in over 60 diseases (loss of vision, glaucoma, CAD etc.) and helps cancers form the new blood vessels needed for the cancer to spread. Dietary fructose and high blood glucose both build up fructose in cells in excess of what is needed for cells to replicate. This can trigger genetic predispositions to diseases your doctors will recognize like Type 2 diabetes, metabolic syndrome, hypertension, high triglycerides, CAD, NASH, depression, retinopathy, PCOS etc. and many they will not. references... <http://www.hindawi.com/journals/jop/2010/170393.html>