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Sadly the AT&T variant of the One X won't see an official Sense 5. AT&T has failed miserably with getting the Sense 4+ update out as the AT&T One X is the last of the One X bunch to see Sense 4+. I wouldn't be surprised if AT&T drops Sense 5 out completely for the device.
1 year, 4 months ago on HTC's Facebook Claims HTC One Series Is Getting Sense 5
Hmm... Currently on my HTC Inspire I'm running MikRunny Sense 3.5. I haven't noticed it slowing down yet, and I've used it for about...3 months? When I used RCMix, I ran the ROM for 8 months in a row, and it never really slowed down.
2 years ago on Editorial: How Long Does An Android ROM Last?