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I used to get heavy blisters too when running on my Vibrams. But I have found out that it was my running technique. I researched a lot about it and change my technique. It helped to minimize blisters on my feet, not to mention aches and pains. Have you looked at barefoot running techniques like POSE, Chi Running, and others?
3 years ago on Dealing with Blisters, Avoiding Ankle Pain and Other Lessons From My Second 5k Race