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@NicholasWeiner Maxis have said earlier that they will release modding tools some time after the release.
2 years ago on Sim City Beta Impressions: The King of City Builders?
@TheFojacko I've heard that the city size Maxis have shown in various videos (and the size found in the closed beta) will be the final size. I think this is due to the fact EA wants the game to be compatible to as many computers as possible.
You won't be able to have any AI neighbours, but you can create private regions which will be only yours.